Controlling false discoveries in candidate gene studies
نویسندگان
چکیده
منابع مشابه
Controlling False Discoveries in Mapping Multiple Phenotypes
The genetic basis of multiple phenotypes such as gene expression, metabolite levels, or imaging features is often investigated by testing a large collection of hypotheses, probing the existence of association between each of the traits and hundred of thousands of genotyped variants. Appropriate multiplicity adjustment is crucial to guarantee replicability of findings, and False Discovery Rate (...
متن کاملControlling the Rate of GWAS False Discoveries
With the rise of both the number and the complexity of traits of interest, control of the false discovery rate (FDR) in genetic association studies has become an increasingly appealing and accepted target for multiple comparison adjustment. While a number of robust FDR-controlling strategies exist, the nature of this error rate is intimately tied to the precise way in which discoveries are coun...
متن کاملControlling false discoveries in genome scans for selection.
Population differentiation (PD) and ecological association (EA) tests have recently emerged as prominent statistical methods to investigate signatures of local adaptation using population genomic data. Based on statistical models, these genomewide testing procedures have attracted considerable attention as tools to identify loci potentially targeted by natural selection. An important issue with...
متن کاملControlling false discoveries in multidimensional directional decisions, with applications to gene expression data on ordered categories.
Microarray gene expression studies over ordered categories are routinely conducted to gain insights into biological functions of genes and the underlying biological processes. Some common experiments are time-course/dose-response experiments where a tissue or cell line is exposed to different doses and/or durations of time to a chemical. A goal of such studies is to identify gene expression pat...
متن کاملMany Phenotypes Without Many False Discoveries: Error Controlling Strategies for Multitrait Association Studies
The genetic basis of multiple phenotypes such as gene expression, metabolite levels, or imaging features is often investigated by testing a large collection of hypotheses, probing the existence of association between each of the traits and hundreds of thousands of genotyped variants. Appropriate multiplicity adjustment is crucial to guarantee replicability of findings, and the false discovery r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2005
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4001581